Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. Bacteria found in the gut of mice affect the liver’s antitumor immune function. The findings have implications for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them.
Researchers have elucidated a mechanism by which ‘good’ bacteria that reside in our gastrointestinal tract can help protect us from inflammation, and how their disruption (dysbiosis) can increase the susceptibility of the liver to more harmful forms of disease. Their study identified two key metabolites produced by the bacteria in mice that modulate inflammation in the host and could ultimately reduce the severity of non-alcoholic fatty liver disease.
Source: Gut check: Metabolites shed by intestinal microbiota keep inflammation at bay: Researchers find inflammatory response in fatty liver disease is reduced by two tryptophan metabolites from gut bacteria — ScienceDaily
Scientists working with laboratory mice have shown that it’s possible to favor the engraftment of one gut bacterial strain over others by manipulating the mice’s diet. The researchers also have shown it’s possible to control how much a bacterium grows in the intestine by calibrating the amount of a specific carbohydrate in each mouse’s water or food.
An investigational new drug offers hope of relief for celiac disease patients who are inadvertently exposed to gluten while on a gluten-free diet. Inadvertent exposure to gluten can be a frequent occurrence for celiac patients that triggers symptoms, such as pain in the gut and diarrhea, due to intestinal damage.
Source: Experimental drug eases effects of gluten for celiac patients on gluten-free diet: First proof-of-concept study shows AMG 714 (anti-IL-15 monoclonal antibody) potentially protects celiac patients from inadvertent gluten exposure — ScienceDaily
Scientists have for the first time found evidence that a microbe in the human gut is associated with protection from typhoid fever infection. If the research is borne out, it could offer an exciting new way to reduce intestinal infections.
Researchers have shown a novel relationship between the intestinal microbiome and atherosclerosis, one of the major causes of heart attack and stroke. This was measured as the burden of plaque in the carotid arteries.
A study sheds new light on the connection between the gut and the brain, untangling the complex interplay that allows the byproducts of microorganisms living in the gut to influence the progression of neurodegenerative diseases.