Switching off insatiable hunger: A new drug to help young patients with genetic obesity

Researchers have successfully treated patients whose obesity is caused by a genetic defect. Aside from its beneficial effects on the patients, the researchers also provided insights into the fundamental signaling pathways regulating satiety of the new drug.

Source: Switching off insatiable hunger: A new drug to help young patients with genetic obesity — ScienceDaily


Hunger overrides sense of fullness after weight loss

The levels of hormones that control hunger and fullness(satiety) both rise after weight loss, but individuals may only experience an increase in hunger, according to a new study.

Source: Hunger overrides sense of fullness after weight loss — ScienceDaily

The Ketogenic Diet

On average, people eat about half of their daily calories through carbohydrates. There are a few problems with this. First of all, when carbs are digested they cause an increase in blood sugar and insulin. Having high levels of insulin over time leads to insulin resistance, which can cause weight gain, prevents satiety, and leads to multiple diseases.

A ketogenic diet, on the other hand, is the ingestion of mostly fats, with a small to moderate amount of protein, and very little carbs. Usually a ketogenic diet will consist of about 5% of daily calories from carbs, 70-80% from fats, and 10-15% from protein.

Being in a state of ketosis, whether nutritional or fasting induced has a great number of very beneficial metabolic effects on the body. The ketogenic diet has been shown to help treat and/or prevent: cancer, diabetes (both types), insulin resistance, heart disease, neurological disorders (ALS, Parkinsons, MS, etc.), and acid reflux. Utilizing a ketogenic diet can also greatly affect weight loss and prevent aging on a cellular level.

In addition to the above health benefits, being in ketosis also helps with mental focus/clarity and increased energy.

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Intermittent Fasting

You may have heard of it before. If not, allow me to enlighten you. Intermittent fasting (IF) is going an extended period of time ingesting zero calories, followed by eating all of your required calories in a short “feeding window.” There are many variations and time frames for each phase. A common variation, and the one I’m using, is a 16/8 fast. This is where you are in a fasted state for 16 hours and eat all your food in a glorious 8 hour window. Sounds crazy? There are actually a great amount of benefits to IF, as far as health, longevity, fat loss, muscle building, and more.

Fat Loss and Muscle Mass

IF has been shown, in multiple studies to lead to healthy and sustainable fat loss, and increased BMR (basal metabolic rate). There have also been multiple studies showing that paired with a resistance training (lifting weights) program, muscle mass has not only not decreased but has increased, albeit in small percentages. Though, for an average male, a gain of 1-2 lbs. of muscle in 2 months is nothing to scoff at.

Health and Longevity

Here are where the benefits of IF really outweigh the discomfort of the first day or two of being hungry. In study after study, IF has been shown to decrease and prevent brain cell senescence, which is basically the process in which your cells age and become less functional. IF has also been shown to promote autophagy, which is where the body destroys dead or malfunctioning cells. This is a vital process to health and living a long healthy life, as it has been linked to the prevention of neurodegenerative diseases (Parkinson’s, Alzheimer’s, etc.), malignancy, and infection (various types of cancer). IF also triggers stem cell regeneration in the immune system, basically renewing your immune system, which has obvious benefits.

So, IF will help you to burn more fat, maintain or build muscle. IF will also boost multiple functions that will lead to a longer and healthier life. And it is surprisingly easy to do.